Development of Two Simple Spectrophotometric Methods to Assay Phenylephrine-HCl as Pure Form And in Its Drug Forms

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چکیده

This work includes the development of two spectrophotometric methods which are sensitive, accurate, stable, and has good recovery for determination phenylephrine-HCl as free form in pharmaceutical preparations. In method (A), phenylephrine is oxidized by potassium permanganate a basic solution sodium hydroxide bluish-green color resulting manganate (MnO 42- ) measured at wavelength 610 nm, linearly proportional to amount phenylephrine-HCl. Method (B), involved oxidation using an excess N-bromosuccinimide acidic medium hydrochloric acid solution, remaining (unreacted) used bleach indigo carmine dye absorbance blue nm. directly concentration The molar absorptivity coefficients (A) (B) estimated equal 1.5722×10 4 5.5191×10 L/mol.cm, respectively. Beer’s law both linear ranges 0.2–8.0 µg/mL (method A) 0.2–3.5 B). relative standard deviation values also found be better than 0.0286 0.0114, proposed applied estimate injection drop.

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ژورنال

عنوان ژورنال: Journal of the Turkish Chemical Society, Section A: Chemistry

سال: 2023

ISSN: ['2149-0120']

DOI: https://doi.org/10.18596/jotcsa.1260666